Anti-Bacillus anthracis pagA/Protective antigen Reference Antibody (Raxibacumab, RUO)
- Catalog number: BS10594
- Availability: In Stock
$326.00
- Ex Tax: $326.00
Description: Raxibacumab (BS10594) is a research-grade recombinant antibody targeting Protective antigen. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-lambda
Species reactivity: Bacillusanthracis
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Protectiveantigen,PA,Anthraxtoxinstranslocatingprotein,PA-83,PA83,ProtectiveantigenPA-20,PA-20,PA20,ProtectiveantigenPA-63,PA-63,PA63,pagA,pag,pXO1-110,BXA0164,GBAA_pXO1_0164
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: CAS:565451-13-0
Background: Protective antigen (PA/pagA) is a ~85 kDa protein. Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax.
References:
1. Bradley, KA. et al. (2001) Nature 414, 225-9. PMID: 11700562
2. Bradley, KA. et al. (2003) The Journal of biological chemistry 278, 49342-7. PMID: 14507921
3. Santelli, E. et al. (2004) Nature 430, 905-8. PMID: 15243628
4. Lacy, DB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 13147-51. PMID: 15326297
5. Singh, Y. et al. (1991) The Journal of biological chemistry 266, 15493-7. PMID: 1651334
6. Mock, M. et al. (2001) Annual review of microbiology 55, 647-71. PMID: 11544370
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-lambda
Species reactivity: Bacillusanthracis
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Protectiveantigen,PA,Anthraxtoxinstranslocatingprotein,PA-83,PA83,ProtectiveantigenPA-20,PA-20,PA20,ProtectiveantigenPA-63,PA-63,PA63,pagA,pag,pXO1-110,BXA0164,GBAA_pXO1_0164
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: CAS:565451-13-0
Background: Protective antigen (PA/pagA) is a ~85 kDa protein. Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax.
References:
1. Bradley, KA. et al. (2001) Nature 414, 225-9. PMID: 11700562
2. Bradley, KA. et al. (2003) The Journal of biological chemistry 278, 49342-7. PMID: 14507921
3. Santelli, E. et al. (2004) Nature 430, 905-8. PMID: 15243628
4. Lacy, DB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 13147-51. PMID: 15326297
5. Singh, Y. et al. (1991) The Journal of biological chemistry 266, 15493-7. PMID: 1651334
6. Mock, M. et al. (2001) Annual review of microbiology 55, 647-71. PMID: 11544370
Note: For research use only. Not suitable for clinical or therapeutic use.
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BioactivitySEC-HPLC detection for Research Grade Brodalumab.
