Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO)
- Catalog number: BS10629
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Erenumab (BS10629) is a research-grade recombinant antibody targeting CGRP type 1 receptor. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG2-lambda
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CGRPtype1receptor,CGRPR,Calcitoninreceptor-likereceptor,CALCRL,Calcitoningene-relatedpeptidetype1receptor
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AMG334,erenumab-aooe,CAS:1582205-90-0
Background: Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
References:
1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767
2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864
3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685
4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG2-lambda
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CGRPtype1receptor,CGRPR,Calcitoninreceptor-likereceptor,CALCRL,Calcitoningene-relatedpeptidetype1receptor
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AMG334,erenumab-aooe,CAS:1582205-90-0
Background: Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
References:
1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767
2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864
3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685
4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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BioactivitySEC-HPLC detection for Research Grade Erenumab.
