Anti-Human IL-33 Reference Antibody (Tozorakimab, RUO)
- Catalog number: BS10702
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Tozorakimab (BS10702) is a research-grade recombinant antibody targeting NF-HEV. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG1-Lambda
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: NF-HEV,IL-1F11,C9orf26,IL-33,Interleukin-1familymember11,IL33,Nuclearfactorfromhighendothelialvenules,NFHEV,Interleukin-33,IL1F11
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MEDI-3506,CAS:2376858-66-9
Background: Interleukin-33 (IL33) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.
References:
1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016
2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166
3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 1785341
4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG1-Lambda
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: NF-HEV,IL-1F11,C9orf26,IL-33,Interleukin-1familymember11,IL33,Nuclearfactorfromhighendothelialvenules,NFHEV,Interleukin-33,IL1F11
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MEDI-3506,CAS:2376858-66-9
Background: Interleukin-33 (IL33) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.
References:
1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016
2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166
3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 1785341
4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Tozorakimab.
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BioactivitySEC-HPLC detection for Research Grade Tozorakimab.
