Human CD369/CLEC7A Recombinant Protein (N-His)
- Catalog number: PH15977
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Human CD369/CLEC7A Protein, N-His (PH15977) expressed in E. coli, spanning Asn123-Met247. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: Asn123-Met247
- Predicted molecular weight: 16.71 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Dectin-1, CD369, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia.
References:
1. Willment, JA. et al. (2001) The Journal of biological chemistry 276, 43818-23. PMID: 11567029
2. Grünebach, F. et al. (2002) Experimental hematology 30, 1309-15. PMID: 12423684
3. Kennedy, AD. et al. (2007) European journal of immunology 37, 467-78. PMID: 17230442 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human CD369/CLEC7A Protein, N-His
