Human MAP3K14 Recombinant Protein (N-His)
- Catalog number: PH16415
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Human MAP3K14 Protein, N-His (PH16415) expressed in E. coli, spanning Ser332-Ser663. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: Ser332-Ser663
- Predicted molecular weight: 38.67 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution.
- Alternative Names: NF-kappa-beta-inducing kinase, NIK, HsNIK, Mitogen-activated protein kinase kinase kinase 14, MAP3K14, Serine/threonine-protein kinase NIK
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) is a ~104 kDa protein. Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner.
References:
1. Willmann, KL. et al. (2014) Nature communications 5, 5360. PMID: 25406581
2. Schlechter, N. et al. (2017) Frontiers in immunology 8, 1624. PMID: 29230214 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human MAP3K14 Protein, N-His
