Anti-Human ADCYAP1/PACAP Reference Antibody (Ald1910, RUO)
- Catalog number: BS10865
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: ALD1910 (BS10865) is a research-grade recombinant antibody targeting Pituitary adenylate cyclase-activating polypeptide. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG2
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 2.27mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Pituitaryadenylatecyclase-activatingpolypeptide,ADCYAP1,PACAP,PACAP-38,PACAP38,PACAP-27,PACAP27,PRP-48
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
References:
1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907
2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469
3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 3204727
4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG2
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 2.27mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Pituitaryadenylatecyclase-activatingpolypeptide,ADCYAP1,PACAP,PACAP-38,PACAP38,PACAP-27,PACAP27,PRP-48
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
References:
1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907
2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469
3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 3204727
4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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BioactivityDetects Recombinant Human ADCYAP1 Protein, N-GST (Cat No.: PH11095) in indirect ELISA.
