Human CLCN7 Recombinant Protein (N-His)
- Catalog number: PH16477
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Human CLCN7 Protein, N-His (PH16477) expressed in E. coli, spanning Phe597-Thr805. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: Phe597-Thr805
- Predicted molecular weight: 26.25 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: Chloride channel 7 alpha subunit, CLCN7, ClC-7, Chloride channel protein 7, H(+)/Cl(-) exchange transporter 7
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: H(+)/Cl(-) exchange transporter 7 (CLCN7) is a ~88 kDa protein. Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
References:
1. Graves, AR. et al. (2008) Nature 453, 788-92. PMID: 18449189
2. Leisle, L. et al. (2011) The EMBO journal 30, 2140-52. PMID: 21527911
3. Nicoli, ER. et al. (2019) American journal of human genetics 104, 1127-1138. PMID: 31155284 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human CLCN7 Protein, N-His
