Human HEPC/Hepcidin Recombinant Protein (N-GST & C-His)
- Catalog number: PH16498
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Human HEPC/Hepcidin Protein, N-GST & C-His (PH16498) expressed in E. coli, spanning Ser25-Thr84. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: Ser25-Thr84
- Predicted molecular weight: 35.12 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: Hepcidin is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
References:
1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227
2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594
3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342
4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human HEPC/Hepcidin Protein, N-GST & C-His
