Anti-Human LILRB2/CD85d/ILT4 Reference Antibody (Jtx-8064-101, RUO)
- Catalog number: BS10878
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: JTX-8064-101 (BS10878) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG4,kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1.94mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CD85antigen-likefamilymemberD,Monocyte/macrophageimmunoglobulin-likereceptor10,MIR-10,ILT4,LIR-2,ILT-4,Immunoglobulin-liketranscript4,MIR10,CD85d,Leukocyteimmunoglobulin-likereceptorsubfamilyBmember2,Leukocyteimmunoglobulin-likereceptor2,LIR2,LILRB2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: JTX-8064
Background: Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens.
References:
1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396
2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576
3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 2044811
5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042
6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
7. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG4,kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1.94mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CD85antigen-likefamilymemberD,Monocyte/macrophageimmunoglobulin-likereceptor10,MIR-10,ILT4,LIR-2,ILT-4,Immunoglobulin-liketranscript4,MIR10,CD85d,Leukocyteimmunoglobulin-likereceptorsubfamilyBmember2,Leukocyteimmunoglobulin-likereceptor2,LIR2,LILRB2
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: JTX-8064
Background: Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens.
References:
1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396
2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576
3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 2044811
5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042
6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
7. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
Note: For research use only. Not suitable for clinical or therapeutic use.
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