Anti-Human VEGF Reference Antibody (Varisacumab, RUO)

Description: Research Grade Varisacumab (BS10045) is a human monoclonal antibody detecting Vascular endothelial growth factor A in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Human
Isotype: IgG1-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: VascularendothelialgrowthfactorA,VPF,VEGFA,VEGF,Vascularpermeabilityfactor,VEGF-A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AT-001,GNR-011,r84,CAS:1610010-60-0
Background: Vascular endothelial growth factor A, long form (Vascular endothelial growth factor A,VPF,VEGFA,VEGF,Vascular permeability factor,VEGF-A) is a ~43 kDa protein. Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A. Involved in protecting cells from hypoxia-mediated cell death.
References:
1. Katsman, M. et al. (2022) Cells 11. PMID: 35455969
Note: For research use only. Not suitable for clinical or therapeutic use.